Literature
On these pages literature in the form of company presentations, posters and articles can be found. The article section gives background on the technology, use of the CaptureSelect ligands in chromatography and contains articles describing the low immunogenicity of the VHH ligands. Slides from oral and poster presentations can be downloaded directly from this site.
Articles
Featured articles
McCue at al (2009), Biogen-Idec, describes the upscaling process of the VIIISelect resin for the purification of b-domain deleted recombinant Factor VIII. High yield and purity together with very high LRVs for process related impurities (HCP, hcDNA and viral clearance) make the media extremely suitable for large scale manufacturing.
Kuroiwa et al, Hematech LLC, shows the specificity of the IgSelect resin for the production of human immunoglobulins in cattle. In a different article in BioPharm International Liu et al, process engineer at Bristol-Myers Squibb, calls IgSelect “A stable alternative to Protein A chromatography”.
Use of ligands in chromatography
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Novel Affinity Ligands Provide for Highly Selective Primary Capture - Bioprocess International February 2010 |
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Biogen Idec – Application of a novel affinity adsorbent for the capture and purification of recombinant factor VIII compounds – J Chromatogr A. November 2009 |
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BMS – Comparison of Camelid Antibody Ligand to Protein A for Monoclonal Antibody Purification - A stable alternative to Protein A chromatography – BioPharm International September 2009 |
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Specific immuno capturing of the staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma - Biotechnol Bioeng. – September 2009 |
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Serum-free production and purification of chimeric IgA antibodies - J Immunol Methods. 2009 July |
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Hematech LLC – Antigen-specific human polyclonal antibodies from hyperimmunized cattle – Nat Biotechnol. February 2009 |
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Proactive Debottlenecking - BioProcess (SPECIAL REPORT, September 2008) |
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Novel affinity ligands for bioprocessing - Innovations in Pharmaceutical Technology 2007, 23, 53-54, 56 |
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| Affinity purification for fewer bottlenecks - Manufacturing chemist oktober 2007 |
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Affinity chromatography based upon unique single chain antibodies - The Peak september 2007 |
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Large-Scale Chromatography - Advanced tool for purification of mAbs, Fab Fragments, and Viruses - GEN april 2007 |
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Verheesen P et al, Beneficial properties of single-domain antibody fragments for application in immunoaffinity purification and immuno-perfusion chromatography. Biochimica et Biophysica Acta 1624: pp21-28, 2003 |
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ten Haaft M, Hermans P and Dawson B, Separations in Proteomics: Use of Camelid Antibody Fragments in the Depletion and Enrichment of Human Plasma Proteins for Proteomics Applications. In: Smejkal G and Lazarev A, Separation Methods in Proteomics. CRC Press. p29-40, 2006 |
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Camelid antibody reviews
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Muyldermans S, Single domain camel antibodies: current status. Reviews in Molecular Biotechnology 74: pp277-302, 2001 |
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Immunogenicity of ligands
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Cortez-Retamozo V et al, Efficient tumor targeting by single-domain antibody fragments of camels. Int. J. Cancer 98: pp456-462, 2002 |
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| Revets H et al, Nanobodies as novel agents for cancer therapy. Expert Opin. Biol. Ther. 5(1): pp111-124, 2005 |  |
Presentations
Presentations
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Peptalk 2010 (San Diego, January 2010) |
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Vaccines Europe 2009 (Brussels, November 2009) |
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BIO-Europe 2009 (Vienna, November 2009) |
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Affinity 2009 (Reykjavik, July 2009) |
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Peptalk 2009 (San Diego, January 2009) |
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Affinity 2007 (New york, July 2007) |
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PPB07 (Elba, May 2007) |
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Posters
Posters
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Improved purification of biotherapeutics using CaptureSelect® affinity ligands - PEGS Europe 2009 (Hannover, October 2009) |
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Improved purification of biotherapeutics using CaptureSelect® affinity ligands - BioPharm America 2009 (San Fransisco, September 2009) |
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Discovery and implementation of novel affinity ligands for therapeutic apheresis |
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Application examples of CaptureSelect® Caustic Stable Human IgG ligand |
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